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IL-17A and IL-17F in tissue homeostasis, inflammation and regeneration

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IL-17 signalling regulates both protective and harmful immune responses; therefore, its complete inhibition can have adverse effects. Detailed consideration and fine-tuning of IL-17-inhibition strategies is needed to selectively regulate disease outcomes.

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Fig. 1: IL-17 signalling in joint inflammation and regeneration.

References

  1. Adamopoulos, I. E. et al. IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis. Ann. Rheum. Dis. 74, 1284–1292 (2015).

    Article  CAS  PubMed  Google Scholar 

  2. Merola, J. F. et al. Bimekizumab in patients with active psoriatic arthritis and previous inadequate response or intolerance to tumour necrosis factor-α inhibitors: a randomised, double-blind, placebo-controlled, phase 3 trial (BE COMPLETE). Lancet 401, 38–48 (2023).

    Article  CAS  PubMed  Google Scholar 

  3. Gaublomme, J. T. et al. Single-cell genomics unveils critical regulators of TH17 cell pathogenicity. Cell 163, 1400–1412 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Su, Y. et al. Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation. Sci. Immunol. 4, eaau9657 (2019).

    Article  CAS  PubMed  Google Scholar 

  5. Ono, T. et al. IL-17-producing γδ T cells enhance bone regeneration. Nat. Commun. 7, 10928 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Mann, A. O. et al. IL-17A-producing γδ T cells promote muscle regeneration in a microbiota-dependent manner. J. Exp. Med. 219, e20211504 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Mamedov, M. R. et al. A macrophage colony-stimulating-factor-producing γδ T cell subset prevents malarial parasitemic recurrence. Immunity 48, 350–363 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Nguyen, C. T. et al. Peripheral γδ T cells regulate neutrophil expansion and recruitment in experimental psoriatic arthritis. Arthritis Rheumatol. 74, 1524–1534 (2022).

    Article  CAS  PubMed  Google Scholar 

  9. Luo, X. IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice. Neuron 109, 2691–2706 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Enamorado, M. et al. Immunity to the microbiota promotes sensory neuron regeneration. Cell 186, 607–620 (2023).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Iannis E. Adamopoulos

  2. Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA

    Vijay Kuchroo

  3. Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Vijay Kuchroo

Authors
  1. Iannis E. Adamopoulos
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  2. Vijay Kuchroo
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Correspondence to Iannis E. Adamopoulos.

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Competing interests

I.E.A. declares that he has received speaker fees, research support and/or served on advisory boards for Novartis, Pfizer and Merck. V.K. declares no competing interests.

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Adamopoulos, I.E., Kuchroo, V. IL-17A and IL-17F in tissue homeostasis, inflammation and regeneration. Nat Rev Rheumatol 19, 535–536 (2023). https://doi.org/10.1038/s41584-023-01004-5

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  • DOI: https://doi.org/10.1038/s41584-023-01004-5

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