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Has lupus anticoagulant testing had its day?

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Antibodies against phosphatidylserine–prothrombin complexes (PS–PT) are one type of antiphospholipid antibody that is responsible for lupus anticoagulant activity. Anti-PS–PT antibodies are not currently included in the classification criteria for antiphospholipid syndrome (APS), but should they replace lupus anticoagulant testing to improve the diagnosis of APS?

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References

  1. Amengual, O. & Atsumi, T. Antiphospholipid syndrome, “the best prophet of the future”. Mod. Rheumatol. 28, 409–416 (2018).

    Article  CAS  Google Scholar 

  2. Miyakis, S. et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J. Thromb. Haemost. 4, 295–306 (2006).

    Article  CAS  Google Scholar 

  3. Sciascia, S. et al. Reliability of lupus anticoagulant and anti-phosphatidylserine/prothrombin autoantibodies in antiphopholipid syndrome: a multicenter study. Front. Immunol. 10, 376 (2019).

    Article  Google Scholar 

  4. Atsumi, T. et al. Association of autoantibodies against the phosphatidylserine-prothrombin complex with manifestations of the antiphospholipid syndrome and with the presence of lupus anticoagulant. Arthritis Rheum. 43, 1982–1993 (2000).

    Article  CAS  Google Scholar 

  5. Galli, M. et al. Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood 101, 1827–1832 (2003).

    Article  CAS  Google Scholar 

  6. Devreese, K. M. et al. Testing for antiphospholipid antibodies with solid phase assays: guidance from the SSC of the ISTH. J. Thromb. Haemost. 12, 792–795 (2014).

    Article  CAS  Google Scholar 

  7. Sciascia, S. et al. Anti-prothrombin (aPT) and anti-phosphatidylserine/prothrombin (aPS/PT) antibodies and the risk of thrombosis in the antiphospholipid syndrome. A systematic review. Thromb. Haemost. 111, 354–364 (2014).

    Article  CAS  Google Scholar 

  8. Amengual, O. et al. Evaluation of phosphatidylserine-dependent antiprothrombin antibody testing for the diagnosis of antiphospholipid syndrome: results of an international multicentre study. Lupus 26, 266–276 (2017).

    Article  CAS  Google Scholar 

  9. Antovic, A. et al. Effects of direct oral anticoagulants on lupus anticoagulant assays in a real-life setting. Thromb. Haemost. 117, 1700–1704 (2017).

    Article  Google Scholar 

  10. Nakamura, H. et al. First-line, non-criterial antiphospholipid antibody testing for the diagnosis of antiphospholipid syndrome in clinical practice: a combination of anti-β2 -glycoprotein I domain I and anti-phosphatidylserine/prothrombin complex antibodies tests. Arthritis Care Res. 70, 627–634 (2018).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

    Yuichiro Fujieda & Tatsuya Atsumi

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  1. Yuichiro Fujieda
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  2. Tatsuya Atsumi
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Correspondence to Tatsuya Atsumi.

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The authors declare no competing interests.

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Fujieda, Y., Atsumi, T. Has lupus anticoagulant testing had its day?. Nat Rev Rheumatol 15, 324–325 (2019). https://doi.org/10.1038/s41584-019-0218-6

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