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Falls, fractures and vitamin D: a never-ending story?

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Vitamin D is important for skeletal metabolism and calcium homeostasis, but conflicting evidence exists as to whether vitamin D supplementation has a protective effect on musculoskeletal outcomes. Do the results of a new meta-analysis bring clarity or increase confusion?

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References

  1. Bouillon, R. et al. Skeletal and extra-skeletal actions of vitamin D: current evidence and outstanding questions. Endocr. Rev. https://doi.org/10.1210/er.2018-00126 (2018).

    Article  PubMed  Google Scholar 

  2. Bolland, M. J., Grey, A. & Avenell, A. Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analyses, and trial-sequential analyses. Lancet Diabetes Endocrinol. 6, 847–858 (2018).

    Article  Google Scholar 

  3. Avenell, A., Mak, J. C. S. & O’Connell, D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst. Rev. 4, CD000227 (2014).

    Google Scholar 

  4. Reid, I. R., Bolland, M. J. & Grey, A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet 383, 146–155 (2014).

    Article  CAS  Google Scholar 

  5. Zhao, J. G. et al. Association between calcium or vitamin D supplementation and fracture incidence in community-dwelling older adults: a systematic review and meta-analysis. JAMA 318, 2466–2482 (2017).

    Article  CAS  Google Scholar 

  6. Holick, M. F. et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 96, 1911–1930 (2011).

    Article  CAS  Google Scholar 

  7. Grant, A. M. et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 365, 1621–1628 (2005).

    Article  CAS  Google Scholar 

  8. Khaw, K. T. et al. Effect of monthly high-dose vitamin D supplementation on falls and non-vertebral fractures: secondary and post-hoc outcomes from the randomised, double-blind, placebo-controlled ViDA trial. Lancet Diabetes Endocrinol. 5, 438–447 (2017).

    Article  CAS  Google Scholar 

  9. Lyons, R. A. et al. Preventing fractures among older people living in institutional care: a pragmatic randomised double blind placebo controlled trial of vitamin D supplementation. Osteoporos. Int. 18, 811–818 (2007).

    Article  CAS  Google Scholar 

  10. Smith, H. et al. Effect of annual intramuscular vitamin D on fracture risk in elderly men and women — a population-based, randomized, double-blind, placebo-controlled trial. Rheumatology 46, 1852–1857 (2007).

    Article  CAS  Google Scholar 

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Correspondence to Luigi Gennari.

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Chiodini, I., Gennari, L. Falls, fractures and vitamin D: a never-ending story?. Nat Rev Rheumatol 15, 6–8 (2019). https://doi.org/10.1038/s41584-018-0135-0

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