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Transition to chronic pain: opportunities for novel therapeutics

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Although chronic pain is one of the most important medical problems facing society, there has been very limited progress in the development of novel therapies for this condition. Here, we discuss high-impact research priorities to reduce the number of people transitioning from acute to chronic intractable pain.

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Acknowledgements

We thank the Interagency Pain Research Coordinating Committee of the US National Institutes of Health, who facilitated and provided financial support for meetings of the working group.

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Authors and Affiliations

  1. The University of Texas at Dallas, Richardson, TX, USA

    Theodore J. Price

  2. University of California, San Francisco, San Francisco, CA, USA

    Allan I. Basbaum, Jacqueline Bresnahan & Jon D. Levine

  3. National Fibromyalgia and Chronic Pain Association, Logan, UT, USA

    Jan F. Chambers

  4. Laval University & CERVO Brain Research Centre, Québec, QC, Canada

    Yves De Koninck

  5. Harvard University, Boston, MA, USA

    Robert R. Edwards & Neil Schechter

  6. Duke University, Durham, NC, USA

    Ru-Rong Ji

  7. York University, Toronto, ON, Canada

    Joel Katz

  8. University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Annemieke Kavelaars

  9. National Institutes of Health, Bethesda, MD, USA

    Linda Porter

  10. University of Iowa, Iowa City, IA, USA

    Kathleen A. Sluka

  11. University of Washington, Seattle, WA, USA

    Gregory W. Terman

  12. University of Colorado, Boulder, CO, USA

    Tor D. Wager

  13. University of California, San Diego, San Diego, CA, USA

    Tony L. Yaksh

  14. University of Rochester, Rochester, NY, USA

    Robert H. Dworkin

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  1. Theodore J. Price
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  2. Allan I. Basbaum
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  3. Jacqueline Bresnahan
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  4. Jan F. Chambers
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  5. Yves De Koninck
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  6. Robert R. Edwards
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  7. Ru-Rong Ji
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  8. Joel Katz
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  9. Annemieke Kavelaars
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  10. Jon D. Levine
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  11. Linda Porter
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  12. Neil Schechter
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  13. Kathleen A. Sluka
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  14. Gregory W. Terman
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  15. Tor D. Wager
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  16. Tony L. Yaksh
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  17. Robert H. Dworkin
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Corresponding author

Correspondence to Theodore J. Price.

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Competing interests

The authors declare no competing interests.

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RELATED LINKS

Federal Pain Research Strategy: https://iprcc.nih.gov/sites/default/files/iprcc/FPRS_Research_Recommendations_Final_508C.pdf

NIH policy: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-15-102.html

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Price, T.J., Basbaum, A.I., Bresnahan, J. et al. Transition to chronic pain: opportunities for novel therapeutics. Nat Rev Neurosci 19, 383–384 (2018). https://doi.org/10.1038/s41583-018-0012-5

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