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Assessing long-term effectiveness of MS treatment — a matter of debate

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Assessment of the long-term effectiveness of disease-modifying therapies in multiple sclerosis is plagued by methodological issues, but statistical methods continue to evolve. Use of a novel approach has highlighted the importance of accounting for cumulative exposure to disease-modifying therapies when assessing the long-term effects of treatment on disability accumulation.

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Authors and Affiliations

  1. Department of Basic Medical Sciences, Neurological Sciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy

    Maria Trojano & Pietro Iaffaldano

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  1. Maria Trojano
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  2. Pietro Iaffaldano
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Correspondence to Maria Trojano.

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Competing interests

M.T. has received research grants for her Institution from Biogen, Merck, Novartis and Roche, and honoraria as a speaker and advisory board member from Biogen, Merck, Novartis, Roche and Sanofi Genzyme. P.I. has served on advisory boards for Biogen, Bayer, Genzyme, Merck Serono, Novartis, Roche and Teva and has received honoraria as a speaker from Biogen Idec, Genzyme, Merck Serono, Novartis, Sanofi Aventis and Teva.

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Trojano, M., Iaffaldano, P. Assessing long-term effectiveness of MS treatment — a matter of debate. Nat Rev Neurol 17, 197–198 (2021). https://doi.org/10.1038/s41582-021-00476-x

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