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ALZHEIMER DISEASE

In search of an anti-inflammatory drug for Alzheimer disease

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Evidence suggests that chronic neuroinflammation has an important role in the pathogenesis of Alzheimer disease. However, in a new clinical trial, the tetracycline antibiotic minocycline, which has anti-inflammatory properties, failed to delay disease progression in individuals with mild Alzheimer disease.

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Fig. 1: Change in sMMSE score from baseline to month 24.

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Authors and Affiliations

  1. Pharmacology Unit, School of Medicine, Western Sydney University, Campbelltown, Australia

    Erika Gyengesi & Gerald Münch

  2. NICM Health Research Institute, Western Sydney University, Westmead, Australia

    Gerald Münch

Authors
  1. Erika Gyengesi
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  2. Gerald Münch
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Correspondence to Gerald Münch.

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The authors declare no competing interests.

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Gyengesi, E., Münch, G. In search of an anti-inflammatory drug for Alzheimer disease. Nat Rev Neurol 16, 131–132 (2020). https://doi.org/10.1038/s41582-019-0307-9

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