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Are electronic health records ready for clinical trial use?

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Routinely collected data from electronic health records (EHRs) could potentially be used to facilitate clinical trials. Use of computational phenotypes shows promise for detecting trial-eligible paediatric patients; however, moving from EHR identification to recruitment requires consideration of legal, ethical and logistical challenges.

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Acknowledgements

L.P. is supported by a National Institute for Health Research (NIHR) Doctoral Research Fellowship DRF-2016-09-055. The views expressed in this publication are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The funding body had no role in the design, collection, analysis or interpretation of data, in the writing of the manuscript, or in the decision to submit the manuscript for publication. D.N. is co-applicant on two GlaxoSmithKline-funded, open-label studies in sub-Saharan Africa that are unrelated to this work.

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Authors and Affiliations

  1. UK Renal Registry, Bristol, UK

    Lucy Plumb & Dorothea Nitsch

  2. Population Health Sciences Institute, University of Bristol Medical School, Bristol, UK

    Lucy Plumb

  3. Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK

    Dorothea Nitsch

Authors
  1. Lucy Plumb
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  2. Dorothea Nitsch
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Correspondence to Dorothea Nitsch.

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The authors declare no competing interests.

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Plumb, L., Nitsch, D. Are electronic health records ready for clinical trial use?. Nat Rev Nephrol 16, 191–192 (2020). https://doi.org/10.1038/s41581-020-0252-2

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