A new study links pathogenic cubilin gene (CUBN) variants to proteinuria without progressive renal impairment, providing reassurance for a subset of patients, calling into question the accepted pathogenesis of glomerulosclerosis and suggesting future therapeutic options.
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Acknowledgements
The author is supported by the Royal Children’s Hospital Foundation, Melbourne Genomics Health Alliance, the KidGen Collaborative and the Australian Genomics Health Alliance. The Murdoch Children’s Research Institute is supported by the Victorian Government’s Operational Infrastructure Support Program.
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Quinlan, C. CUBN variants uncouple proteinuria from kidney function. Nat Rev Nephrol 16, 135–136 (2020). https://doi.org/10.1038/s41581-019-0242-4
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DOI: https://doi.org/10.1038/s41581-019-0242-4
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