A genetic study using a Mendelian randomization approach provides evidence that albuminuria — as well as being the result of hypertension — might also cause hypertension and cardiometabolic disease. We suggest that a mechanism behind these findings could involve sodium retention by urinary protein-induced activation of the epithelial sodium channel in the distal tubule.
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Gansevoort, R.T., Snieder, H. Albuminuria as a cause of hypertension. Nat Rev Nephrol 15, 6–8 (2019). https://doi.org/10.1038/s41581-018-0073-8
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DOI: https://doi.org/10.1038/s41581-018-0073-8
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