Two new clinical trials together involving nearly 30,000 patients support previous observational evidence that the most common solution used for intravenous fluid therapy in the world is associated with kidney damage. Both trials found that 0.9% saline was inferior to solutions with more physiological chloride concentrations and resulted in greater rates of major adverse kidney events.
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J.A.K. has received consulting fees and grant support from Baxter for unrelated research. J.A.K. is also a co-investigator for the Balanced Solution versus Saline in Intensive Care Study (BaSICS) (NCT02875873).
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Kellum, J.A. Abnormal saline and the history of intravenous fluids. Nat Rev Nephrol 14, 358–360 (2018). https://doi.org/10.1038/s41581-018-0008-4
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DOI: https://doi.org/10.1038/s41581-018-0008-4
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