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The BCL-2 family saga

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References

Original articles

  • Lovell, J. F. et al. Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. Cell 135, 1074–1084 (2008)

    Article  CAS  Google Scholar 

  • Edlich, F. et al. Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol. Cell 145, 104–116 (2011)

    Article  CAS  Google Scholar 

  • Czabotar et al. Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis. Cell 152, 519–531 (2013)

    Article  CAS  Google Scholar 

  • Ichim et al. Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death. Mol. Cell 57, 860–872 (2015)

    Article  CAS  Google Scholar 

  • McArthur, K. et al. BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. Science 23, eaao6047 (2018)

    Article  Google Scholar 

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Correspondence to Ana J. García-Sáez.

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García-Sáez, A.J. The BCL-2 family saga. Nat Rev Mol Cell Biol 21, 564–565 (2020). https://doi.org/10.1038/s41580-020-0276-2

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