References
Original articles
Lovell, J. F. et al. Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. Cell 135, 1074–1084 (2008)
Edlich, F. et al. Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol. Cell 145, 104–116 (2011)
Czabotar et al. Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis. Cell 152, 519–531 (2013)
Ichim et al. Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death. Mol. Cell 57, 860–872 (2015)
McArthur, K. et al. BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. Science 23, eaao6047 (2018)
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García-Sáez, A.J. The BCL-2 family saga. Nat Rev Mol Cell Biol 21, 564–565 (2020). https://doi.org/10.1038/s41580-020-0276-2
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DOI: https://doi.org/10.1038/s41580-020-0276-2
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