This month’s Genome Watch explores how synonymous mutations may have wider implications for protein function than previously acknowledged.
References
Harvey, A. L., Edrada-Ebel, R. & Quinn, R. J. The re-emergence of natural products for drug discovery in the genomics era. Nat. Rev. Drug Discov. 14, 111–129 (2015).
Overmann, J., Abt, B. & Sikorski, J. Present and future of culturing bacteria. Annu. Rev. Microbiol. 71, 711–730 (2017).
Jiang, Y. et al. How synonymous mutations alter enzyme structure and function over long timescales. Nat. Chem. https://doi.org/10.1038/s41557-022-01091-z (2022).
Shen, X. et al. Synonymous mutations in representative yeast genes are mostly strongly non-neutral. Nature 606, 725–731 (2022).
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Grosjean, N., Blaby, I.K. Whisperings from not so silent mutations. Nat Rev Microbiol 21, 221 (2023). https://doi.org/10.1038/s41579-023-00864-8
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DOI: https://doi.org/10.1038/s41579-023-00864-8
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