Skip to main content
SpringerLink
Log in

New keys to unlock the treasure trove of microbial natural products

  • Genome Watch
  • Published:

From Nature Reviews Microbiology

View current issue Sign up to alerts

This month’s Genome Watch highlights how recent advances in computational identification of biosynthetic gene clusters (BGCs), and in their experimental manipulation, are opening new avenues to access novel secondary metabolites.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Kautsar, S. A. et al. BiG-FAM: the biosynthetic gene cluster families database. Nucleic Acids Res. 49, D490–D497 (2021).

    Article  CAS  Google Scholar 

  2. Qi, Y., Nepal, K. K. & Blodgett, J. A. V. A comparative metabologenomic approach reveals mechanistic insights into Streptomyces antibiotic crypticity. Proc. Natl Acad. Sci. USA 118, e2103515118 (2021).

    Article  CAS  Google Scholar 

  3. Park, J., Yim, S. S. & Wang, H. H. High-throughput transcriptional characterization of regulatory sequences from bacterial biosynthetic gene clusters. ACS Synth. Biol. 10, 1859–1873 (2021).

    Article  CAS  Google Scholar 

  4. Enghiad, B. et al. Cas12a-assisted precise targeted cloning using in vivo Cre-lox recombination. Nat. Commun. 12, 1171 (2021).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. DOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, USA

    Daniel W. Udwary, Hiroshi Otani & Nigel J. Mouncey

Authors
  1. Daniel W. Udwary
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hiroshi Otani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nigel J. Mouncey
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nigel J. Mouncey.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Udwary, D.W., Otani, H. & Mouncey, N.J. New keys to unlock the treasure trove of microbial natural products. Nat Rev Microbiol 19, 683 (2021). https://doi.org/10.1038/s41579-021-00631-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41579-021-00631-7

  • Springer Nature Limited

Search

Navigation