Skip to main content
SpringerLink
Log in

The OrganiX microfluidic system to recreate the complex tumour microenvironment

  • Tools of the Trade
  • Published:

From Nature Reviews Immunology

View current issue Sign up to alerts

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Microfluidic device for vascularized 3D tumour models.

References

  1. Lee, S. W. L. et al. Characterizing the role of monocytes in T cell cancer immunotherapy using a 3D microfluidic model. Front. Immunol. 9, 416 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Lam, M. S. Y. et al. G9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered T cells against hepatocellular carcinoma. Nat. Comm. 14, 563 (2023).

    Article  CAS  Google Scholar 

  3. Lam, M. S. et al. Unveiling the influence of tumor microenvironment and spatial heterogeneity on temozolomide resistance in glioblastoma using an advanced human in vitro model of the blood‐brain barrier and glioblastoma. Small 19, e2302280 (2023).

    Article  PubMed  Google Scholar 

  4. Vasudevan, J. et al. Microphysiological vascularized solid liver tumor model for drug and cell therapy [abstract 4612]. Cancer Res. 83, 4612 (2023).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

    Giulia Adriani

  2. Department of Biomedical Engineering, National University of Singapore (NUS), Singapore, Singapore

    Giulia Adriani

  3. Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore

    Andrea Pavesi

  4. Mechanobiology Institute, NUS, Singapore, Singapore

    Andrea Pavesi

Authors
  1. Giulia Adriani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrea Pavesi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Giulia Adriani or Andrea Pavesi.

Ethics declarations

Competing interests

G.A. and A.P. are co-inventors on a US patent application (US20240018483A1) and an international patent application (WO 2022/197254 A1) describing microfluidic technologies and a method for 3D vascularization. G.A. and A.P. are co-inventors of the OrganiXTM plate, licensed to AIM Biotech. A.P. is a consultant and shareholder of AIM Biotech Pte. Ltd.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Adriani, G., Pavesi, A. The OrganiX microfluidic system to recreate the complex tumour microenvironment. Nat Rev Immunol 24, 307 (2024). https://doi.org/10.1038/s41577-024-01011-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41577-024-01011-x

  • Springer Nature Limited

Search

Navigation