Skip to main content
Log in

Principles of disease defence in organisms, superorganisms and societies

  • Comment
  • Published:

From Nature Reviews Immunology

View current issue Sign up to alerts

Social distancing is an effective way to prevent the spread of disease in societies, whereas infection elimination is a key element of organismal immunity. Here, we discuss how the study of social insects such as ants — which form a superorganism of unconditionally cooperative individuals and thus represent a level of organization that is intermediate between a classical society of individuals and an organism of cells — can help to determine common principles of disease defence across levels of organization.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: Disease defence across organizational levels.

References

  1. Stockmaier, S. et al. Infectious diseases and social distancing in nature. Science 371, eabc8881 (2021).

    Article  PubMed  Google Scholar 

  2. Stroeymeyt, N. et al. Social network plasticity decreases disease transmission in a eusocial insect. Science 362, 941–945 (2018).

    Article  PubMed  Google Scholar 

  3. Boomsma, J. J. & Gawne, R. Superorganismality and caste differentiation as points of no return: how the major evolutionary transitions were lost in translation. Biol. Rev. 93, 28–54 (2018).

    Article  PubMed  Google Scholar 

  4. Cremer, S. & Sixt, M. Analogies in the evolution of individual and social immunity. Phil. Trans. Roy. Soc. B 364, 129–142 (2009).

    Article  Google Scholar 

  5. Pull, C. D. & McMahon, D. P. Superorganism immunity: a major transition in immune system evolution. Front. Ecol. Evol. https://doi.org/10.3389/fevo.2020.00186 (2020).

    Article  Google Scholar 

  6. Pull, C. D. et al. Destructive disinfection of infected brood prevents systemic disease spread in ant colonies. eLife 7, e32073 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Heyman, Y., Shental, N., Brandis, A., Hefetz, A. & Feinerman, O. Ants regulate colony spatial organization using multiple chemical road-signs. Nat. Comm. 8, 15414 (2017).

    Article  Google Scholar 

  8. Engelmann, B. & Massberg, S. Thrombosis as an intravascular effector of innate immunity. Nat. Rev. Immunol. 13, 34–45 (2013).

    Article  PubMed  Google Scholar 

  9. Schiller, M., Ben-Shaanan, T. L. & Rolls, A. Neuronal regulation of immunity: why, how and where? Nat. Rev. Immunol. 21, 20–36 (2021).

    Article  PubMed  Google Scholar 

  10. Kawagoe, K. et al. Epidemic dynamics in inhomogeneous populations and the role of superspreaders. Phys. Rev. Res. 3, 033283 (2021).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sylvia Cremer.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cremer, S., Sixt, M. Principles of disease defence in organisms, superorganisms and societies. Nat Rev Immunol 22, 713–714 (2022). https://doi.org/10.1038/s41577-022-00797-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41577-022-00797-y

  • Springer Nature Limited

Navigation