Human telomerase reverse transcriptase (hTERT) activity is tightly controlled. This report shows that hTERT is primarily regulated by alternative splicing; skipping of exon 2 triggers decay of TERT mRNA in differentiated cells and its retention promotes telomere maintenance in pluripotent cells.
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Penev, A. et al. Alternative splicing is a developmental switch for hTERT expression. Mol. Cell https://doi.org/10.1016/j.molcel.2021.03.033 (2021)
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Barranco, C. Alternative splicing regulates telomerase repression. Nat Rev Genet 22, 414 (2021). https://doi.org/10.1038/s41576-021-00372-6
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DOI: https://doi.org/10.1038/s41576-021-00372-6
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