References
Original article
Jin, S. et al. Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice. Science https://doi.org/10.1126/science.aaw7166 (2019)
Zuo, E. et al. Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos. Science https://doi.org/10.1126/science.aav9973 (2019)
Further reading
Rees, H. A. & Liu, D. R. Base editing: precision chemistry on the genome and transcriptome of living cells. Nat. Rev. Genet. 19, 770–788 (2018)
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Wrighton, K.H. Cytosine base editors go off-target. Nat Rev Genet 20, 254–255 (2019). https://doi.org/10.1038/s41576-019-0110-x
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DOI: https://doi.org/10.1038/s41576-019-0110-x
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