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GUT MICROBIOTA

Gut bacteria go on record

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From Nature Reviews Gastroenterology & Hepatology

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Microbiota profiling using stool samples is limited in its ability to represent intestinal microbial dynamics. CRISPR-engineered bacteria can be used to acquire cellular RNAs and create a gene expression ‘memory’ during gastrointestinal transit, with the potential to capture microbial transcriptomic changes in the gastrointestinal tract without invasive sampling.

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Fig. 1: Experimental use cases of Record-seq in the gut microbiome.

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Authors and Affiliations

  1. W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Alexander Crits-Christoph & Jotham Suez

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  1. Alexander Crits-Christoph
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  2. Jotham Suez
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Correspondence to Jotham Suez.

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The authors declare no competing interests.

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Crits-Christoph, A., Suez, J. Gut bacteria go on record. Nat Rev Gastroenterol Hepatol 19, 557–558 (2022). https://doi.org/10.1038/s41575-022-00653-3

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