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Safety of in utero exposure to maternal IBD pharmacotherapies

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From Nature Reviews Gastroenterology & Hepatology

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Although available clinical outcome data are reassuring, the consequences of in utero exposure to inflammatory bowel disease (IBD) pharmacotherapies on the development of the neonatal immune system remain ill-defined. So too does the converse effect on immunological maturation of fetal exposure to maternal inflammatory activity. Both warrant elucidation to appropriately stratify antenatal IBD care.

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Fig. 1: Competing risks of exposure to inflammation and immunomodulators in utero.

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Acknowledgements

R.E.P. is funded by an Australian Government Research Training Program Scholarship. C.A.N.-P. is funded by an NHMRC Investigator Grant Leadership 1 (grant 1173584). The authors were also supported by the Victorian State Government Operational Infrastructure Scheme. M.F.N. is funded by the Fielding Fellowship 2017 by the Fielding Foundation.

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Authors and Affiliations

  1. Gastroenterology Department, Monash Health, Melbourne, Victoria, Australia

    Ralley E. Prentice, Sally J. Bell & Rimma Goldberg

  2. School of Clinical Sciences, Department of Medicine, Monash University, Melbourne, Victoria, Australia

    Ralley E. Prentice, Sally J. Bell & Rimma Goldberg

  3. St Vincent’s Hospital Melbourne, Melbourne, Victoria, Australia

    Ralley E. Prentice

  4. Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia

    Ralley E. Prentice, Claudia A. Nold-Petry, Marcel F. Nold & Rimma Goldberg

  5. Department of Paediatrics, Monash University, Melbourne, Victoria, Australia

    Claudia A. Nold-Petry & Marcel F. Nold

  6. Monash Newborn, Monash Children’s Hospital, Melbourne, Victoria, Australia

    Marcel F. Nold

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  1. Ralley E. Prentice
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  2. Sally J. Bell
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  3. Claudia A. Nold-Petry
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  4. Marcel F. Nold
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  5. Rimma Goldberg
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Correspondence to Rimma Goldberg.

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Prentice, R.E., Bell, S.J., Nold-Petry, C.A. et al. Safety of in utero exposure to maternal IBD pharmacotherapies. Nat Rev Gastroenterol Hepatol 19, 213–214 (2022). https://doi.org/10.1038/s41575-021-00572-9

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