Faecal microbiota transplantation (FMT) aims to restore an altered microbiota and has been suggested as a potential treatment option for irritable bowel syndrome (IBS), among other diseases. A new study suggests that the use of a so-called superdonor is necessary to successfully treat patients with IBS using FMT.
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References
König, J. et al. Consensus report: faecal microbiota transfer - clinical applications and procedures. Aliment. Pharmacol. Ther. 45, 222–239 (2017).
El-Salhy, M., Hatlebakk, J. G., Gilja, O. H., Brathen Kristoffersen, A. & Hausken, T. Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study. Gut https://doi.org/10.1136/gutjnl-2019-319630 (2019).
Johnsen, P. H. et al. Faecal microbiota transplantation versus placebo for moderate-to-severe irritable bowel syndrome: a double-blind, randomised, placebo-controlled, parallel-group, single-centre trial. Lancet Gastroenterol. Hepatol. 3, 17–24 (2018).
Halkjaer, S. I. et al. Faecal microbiota transplantation alters gut microbiota in patients with irritable bowel syndrome: results from a randomised, double-blind placebo-controlled study. Gut 67, 2107–2115 (2018).
Holster, S. et al. The effect of allogenic versus autologous fecal microbiota transfer on symptoms, visceral perception and fecal and mucosal microbiota in irritable bowel syndrome: a randomized controlled study. Clin. Transl Gastroenterol. 10, e00034 (2019).
Aroniadis, O. C. et al. Faecal microbiota transplantation for diarrhoea-predominant irritable bowel syndrome: a double-blind, randomised, placebo-controlled trial. Lancet Gastroenterol. Hepatol. 4, 675–685 (2019).
Kootte, R. S. et al. Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition. Cell Metab. 26, 611–619.e6 (2017).
Moayyedi, P. et al. Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology 149, 102–109.e6 (2015).
Wilson, B. C., Vatanen, T., Cutfield, W. S. & O’Sullivan, J. M. The super-donor phenomenon in fecal microbiota transplantation. Front. Cell. Infect. Microbiol. 9, 2 (2019).
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König, J., Brummer, R.J. Faecal microbiota transplantation in IBS — new evidence for success?. Nat Rev Gastroenterol Hepatol 17, 199–200 (2020). https://doi.org/10.1038/s41575-020-0282-z
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DOI: https://doi.org/10.1038/s41575-020-0282-z
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