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STEM CELLS

A new model of intestinal epithelial regeneration: could patients benefit?

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From Nature Reviews Gastroenterology & Hepatology

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A new study has identified an intestinal stem cell population involved in epithelial regeneration upon injury in mice and provided an in vitro tool with which to characterize the recurrent damage–repair mechanisms affecting chronic gastrointestinal inflammatory disorders, including inflammatory bowel disease.

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Fig. 1: Applications of a novel model to investigate intestinal epithelial regeneration.

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Acknowledgements

The authors thank J. Moore for English-language editorial assistance. I.D. is funded by the Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020), Grant 720905. A.S. is funded by the Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) and Grant RTI2018-096946-B-I00 from the Ministerio de Ciencia, Innovación y Universidades, Spain.

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Authors and Affiliations

  1. Inflammatory Bowel Disease Unit, Department of Gastroenterology, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) – CIBEREHD, Barcelona, Spain

    Isabella Dotti & Azucena Salas

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  1. Isabella Dotti
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  2. Azucena Salas
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Correspondence to Azucena Salas.

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The authors declare no competing interests.

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Dotti, I., Salas, A. A new model of intestinal epithelial regeneration: could patients benefit?. Nat Rev Gastroenterol Hepatol 17, 137–138 (2020). https://doi.org/10.1038/s41575-020-0267-y

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