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Environmental stimuli and gut inflammation via dysbiosis in mouse and man

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A new study sheds further light on the interplay between environmental stimuli, the gut microbiota and intestinal inflammation. Identification of modifiable environmental triggers and the mechanisms by which they act has implications for the prevention and treatment of inflammatory bowel disease.

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Fig. 1: Schematic putting results from Lee et al. into context.

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Correspondence to Charlie W. Lees.

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Competing interests

C.L. is funded by a UKRI Future Leaders Fellowship and has received additional research support from AbbVie, Chief Scientist’s Office, Cure Crohn’s Colitis and Gilead. He has received consultancy fees from AbbVie, Dr Falk, Gilead, Hospira, Iterative Scopes, Janssen, Oshi Health, Pfizer, Takeda, Trellus Health and Vifor Pharma. He has received speaking fees and travel support from AbbVie, Dr. Falk, Ferring, Gilead, Hospira, Janssen, Pfizer and Takeda.

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Lees, C.W. Environmental stimuli and gut inflammation via dysbiosis in mouse and man. Nat Rev Gastroenterol Hepatol 17, 715–716 (2020). https://doi.org/10.1038/s41575-020-00373-6

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