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GUT MICROBIOTA

Building community in the gut: a role for mucosal serotonin

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A new study reveals that a novel serotonin sensor in the spore-forming gut bacteria, Turicibacter sanguinis, might be important for host lipid and steroid metabolism. These findings support the emerging concept that bidirectional signalling pathways can influence bacterial community structure and exert effects on host physiology.

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Fig. 1: Turicibacter alters host physiology via a novel serotonin sensor.

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Authors and Affiliations

  1. Center for Inflammatory Bowel Diseases, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA

    Jill M. Hoffman

  2. Department of Pediatrics, Division of Pediatric Gastroenterology, Columbia University Irving Medical Center, New York, NY, USA

    Kara G. Margolis

Authors
  1. Jill M. Hoffman
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  2. Kara G. Margolis
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Correspondence to Kara G. Margolis.

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The authors declare no competing interests

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Hoffman, J.M., Margolis, K.G. Building community in the gut: a role for mucosal serotonin. Nat Rev Gastroenterol Hepatol 17, 6–8 (2020). https://doi.org/10.1038/s41575-019-0227-6

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