Skip to main content

Advertisement

SpringerLink
Log in

COLORECTAL CANCER

Does early metastatic seeding occur in colorectal cancer?

  • News & Views
  • Published:

From Nature Reviews Gastroenterology & Hepatology

View current issue Sign up to alerts

During the metastatic process, cancer cells spread from the primary tumour to distant organs. Although metastases are the primary cause of cancer mortality, the dynamics of the metastatic process remain largely unknown. A new study suggests that during colorectal cancer progression, metastatic seeding might occur before clinical detectability.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Early metastatic seeding in a subset of CRCs.

References

  1. Siegel, R. L., Miller, K. D. & Jemal, A. Cancer statistics, 2019. CA Cancer J. Clin 69, 7–34 (2019).

    Article  Google Scholar 

  2. Turajlic, S. & Swanton, C. Metastasis as an evolutionary process. Science 352, 169–175 (2016).

    Article  CAS  Google Scholar 

  3. Jones, S. et al. Comparative lesion sequencing provides insights into tumor evolution. Proc. Natl Acad. Sci. USA 105, 4283–4288 (2008).

    Article  CAS  Google Scholar 

  4. Hu, Z. et al. Quantitative evidence for early metastatic seeding in colorectal cancer. Nat. Genet. 51, 1113–1122 (2019).

    Article  CAS  Google Scholar 

  5. Ryser, M. D. et al. Spatial mutation patterns as markers of early colorectal tumor cell mobility. Proc. Natl Acad. Sci. USA 115, 5774–5779 (2018).

    Article  CAS  Google Scholar 

  6. Consortium, A. P. G. AACR Project GENIE: Powering Precision Medicine through an International Consortium. Cancer Discov. 7, 818–831 CD-17-0151 (2017).

    Article  Google Scholar 

  7. Doubeni, C. A. et al. Effectiveness of screening colonoscopy in reducing the risk of death from right and left colon cancer: a large community-based study. Gut 67, 291–298 (2018).

    Article  Google Scholar 

  8. Lauby-Secretan, B. et al. The IARC Perspective on Colorectal Cancer Screening. N. Engl. J. Med. 378, 1734–1740 (2018).

    Article  Google Scholar 

  9. Naxerova, K. et al. Origins of lymphatic and distant metastases in human colorectal cancer. Science 357, 55–60 (2017).

    Article  CAS  Google Scholar 

  10. Siravegna, G. et al. Integrating liquid biopsies into the management of cancer. Nat. Rev. Clin. Oncol. 14, 531–548 (2017).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors thank Federica Di Nicolantonio for critically reading the manuscript. Research by A.B. is supported by the Fondazione AIRC per la Ricerca sul Cancro under 5 per Mille 2018 (project 21091), AIRC investigator grant 2018 (project 21923) and Fondazione Piemontese per la Ricerca sul Cancro ONLUS 5 per mille 2014.

Author information

Authors and Affiliations

  1. Candiolo Cancer Institute FPO-IRCCS, Candiolo, Italy

    Alessandro Magrì & Alberto Bardelli

  2. Department of Oncology, University of Torino, Candiolo, Italy

    Alessandro Magrì & Alberto Bardelli

Authors
  1. Alessandro Magrì
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alberto Bardelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alberto Bardelli.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Magrì, A., Bardelli, A. Does early metastatic seeding occur in colorectal cancer?. Nat Rev Gastroenterol Hepatol 16, 651–653 (2019). https://doi.org/10.1038/s41575-019-0200-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41575-019-0200-4

  • Springer Nature Limited

This article is cited by

Search

Navigation