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HOTAIR underlies the region-specific development of adipose tissue

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The long non-coding RNA HOTAIR is exclusively expressed in gluteofemoral subcutaneous adipose tissue (GSAT) and is functionally required for GSAT adipocyte differentiation. A genetic variation analysis showed that the minor allele of rs1443512 is associated with reduced HOTAIR expression and decreased adipose tissue mass in the leg and gynoid regions.

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Fig. 1: A genetic variant located in the HOXC locus contributes to adipose tissue distribution.

References

  1. Gesta, S., Tseng, Y. H. & Kahn, C. R. Developmental origin of fat: tracking obesity to its source. Cell 131, 242–256 (2007).

    Article  CAS  Google Scholar 

  2. Tran, T. T. & Kahn, C. R. Transplantation of adipose tissue and stem cells: role in metabolism and disease. Nat. Rev. Endocrinol. 6, 195–213 (2010).

    Article  Google Scholar 

  3. Pinnick, K. E. et al. Distinct developmental profile of lower-body adipose tissue defines resistance against obesity-associated metabolic complications. Diabetes 63, 3785–3797 (2014).

    Article  CAS  Google Scholar 

  4. Tchoukalova, Y. D. et al. Regional differences in cellular mechanisms of adipose tissue gain with overfeeding. Proc. Natl Acad. Sci. USA 107, 18226–18231 (2010).

    Article  CAS  Google Scholar 

  5. Sun, L. & Lin, J. D. Function and mechanism of long noncoding RNAs in adipocyte biology. Diabetes 68, 887–896 (2019).

    Article  CAS  Google Scholar 

  6. Kuo, F. C. et al. HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution. Cell Rep. 40, 111136 (2022).

    Article  CAS  Google Scholar 

  7. Kalwa, M. et al. The lncRNA HOTAIR impacts on mesenchymal stem cells via triple helix formation. Nucleic Acids Res. 44, 10631–10643 (2016).

    Article  CAS  Google Scholar 

  8. Kuo, F. C. et al. Aberrant overexpression of HOTAIR inhibits abdominal adipogenesis through remodelling of genome-wide DNA methylation and transcription. Mol. Metab. 60, 101473 (2022).

    Article  CAS  Google Scholar 

  9. Ding, C. et al. De novo reconstruction of human adipose transcriptome reveals conserved lncRNAs as regulators of brown adipogenesis. Nat. Commun. 9, 1329 (2018).

    Article  Google Scholar 

  10. Garg, A. Clinical review: lipodystrophies: genetic and acquired body fat disorders. J. Clin. Endocrinol. Metab. 96, 3313–3325 (2011).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, Singapore

    Dan Xu & Lei Sun

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  1. Dan Xu
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  2. Lei Sun
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Correspondence to Lei Sun.

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The authors declare no competing interests.

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Xu, D., Sun, L. HOTAIR underlies the region-specific development of adipose tissue. Nat Rev Endocrinol 18, 663–664 (2022). https://doi.org/10.1038/s41574-022-00754-8

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