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Novel mechanisms of pain in painful diabetic neuropathy

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A recent study has generated compelling experimental data on the role of GPR177 and WNT5a in the pathogenesis and treatment of painful diabetic neuropathy (PDN). The clinical value of these translational findings should be interpreted with caution. However, the limited efficacy of current treatments for PDN warrants further clinical studies on these novel pathways.

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Authors and Affiliations

  1. Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar

    Rayaz A. Malik

  2. Institute of Cardiovascular Science, University of Manchester, Manchester, UK

    Rayaz A. Malik

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  1. Rayaz A. Malik
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Correspondence to Rayaz A. Malik.

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Competing interests

R.M. has received honoraria for talks on painful neuropathy from Pfizer and Proctor and Gamble.

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Malik, R.A. Novel mechanisms of pain in painful diabetic neuropathy. Nat Rev Endocrinol 18, 459–460 (2022). https://doi.org/10.1038/s41574-022-00710-6

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