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PITUITARY GLAND

The human pituitary master gland stripped to single-cell resolution

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Stem cells in the pituitary master gland remain mystifying; moreover, they have hardly been explored in humans. A new study applied transcriptome and chromatin accessibility profiling at single-cell resolution to human postmortem pituitary glands from individuals of different ages, thereby providing insights into the heterogeneity and regulatory mechanisms of the projected human pituitary stem cell population.

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Fig. 1: Setup and considerations of the human pituitary single-nucleus profiling study.

References

  1. Chen, J. et al. The adult pituitary contains a cell population displaying stem/progenitor cell and early embryonic characteristics. Endocrinology 146, 3985–3998 (2005).

    Article  CAS  Google Scholar 

  2. Zhang, Z. et al. Single nucleus transcriptome and chromatin accessibility of postmortem human pituitaries reveal diverse stem cell regulatory mechanisms. Cell Rep. 38, 110467 (2022).

    Article  CAS  Google Scholar 

  3. Ruf-Zamojski, F. et al. Single nucleus multi-omics regulatory landscape of the murine pituitary. Nat. Commun. 12, 2677 (2021).

    Article  CAS  Google Scholar 

  4. Vennekens, A. et al. Interleukin-6 is an activator of pituitary stem cells upon local damage, a competence quenched in the aging gland. Proc. Natl Acad. Sci. USA 118, e2100052118 (2021).

    Article  CAS  Google Scholar 

  5. Laporte, E. et al. Decoding the activated stem cell phenotype of the vividly maturing neonatal pituitary. Preprint at bioRxiv https://doi.org/10.1101/2022.01.18.476723 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Zhang, S. et al. Single-cell transcriptomics identifies divergent developmental lineage trajectories during human pituitary development. Nat. Commun. 11, 5275 (2020).

    Article  CAS  Google Scholar 

  7. Fauquier, T., Rizzoti, K., Dattani, M., Lovell-Badge, R. & Robinson, I. C. A. F. SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland. Proc. Natl Acad. Sci. USA 105, 2907–2912 (2008).

    Article  CAS  Google Scholar 

  8. Russell, J. P. et al. Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells. eLife 10, e59142 (2021).

    Article  CAS  Google Scholar 

  9. Zhu, X., Tollkuhn, J., Taylor, H. & Rosenfeld, M. G. Notch-dependent pituitary SOX2+ stem cells exhibit a timed functional extinction in regulation of the postnatal gland. Stem Cell Reports 5, 1196–1209 (2015).

    Article  CAS  Google Scholar 

  10. Zhu, X., Gleiberman, A. S. & Rosenfeld, M. G. Molecular physiology of pituitary development: signaling and transcriptional networks. Physiol. Rev. 87, 933–963 (2007).

    Article  CAS  Google Scholar 

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Acknowledgements

We thank L. Hemeryck (KU Leuven, Belgium) for her help in creating the first version of the figure.

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Authors and Affiliations

  1. Laboratory of Tissue Plasticity in Health and Disease, Cluster of Stem Cell and Developmental Biology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium

    Emma Laporte & Hugo Vankelecom

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  1. Emma Laporte
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  2. Hugo Vankelecom
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Correspondence to Hugo Vankelecom.

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The authors declare no competing interests.

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Related links

Interactive web portal: http://snpituitaryatlas.princeton.edu/

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Laporte, E., Vankelecom, H. The human pituitary master gland stripped to single-cell resolution. Nat Rev Endocrinol 18, 395–396 (2022). https://doi.org/10.1038/s41574-022-00696-1

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