Skip to main content
SpringerLink
Log in

ADIPOSE TISSUE

Functional diversity of human adipose tissue revealed by spatial mapping

  • News & Views
  • Published:

From Nature Reviews Endocrinology

View current issue Sign up to alerts

By mapping the spatial organization of adipose tissue, Bäckdahl and colleagues identify adipocyte progenitor structures as well as three subclasses of adipocytes with different molecular functions, including insulin sensitivity and leptin signalling.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Mapping the microarchitecture of human adipose tissue.

References

  1. Sakaguchi, M. et al. Adipocyte dynamics and reversible metabolic syndrome in mice with an inducible adipocyte-specific deletion of the insulin receptor. Cell Metab. 25, 448–462 (2017).

    Article  CAS  Google Scholar 

  2. Shao, M. et al. De novo adipocyte differentiation from Pdgfrβ + preadipocytes protects against pathologic visceral adipose expansion in obesity. Nat Commun. 9, 890 (2018).

    Article  Google Scholar 

  3. Schwalie, P. C. et al. A stromal cell population that inhibits adipogenesis in mammalian fat depots. Nature 559, 103–108 (2018).

    Article  CAS  Google Scholar 

  4. Merrick, D. et al. Identification of a mesenchymal progenitor cell hierarchy in adipose tissue. Science 364, eaav2501 (2019).

    Article  CAS  Google Scholar 

  5. Sárvári, A. K. et al. Plasticity of epididymal adipose tissue in response to diet-induced obesity at single-nucleus resolution. Cell Metab. 33, 437–453 (2021).

    Article  Google Scholar 

  6. Sun, W. et al. snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis. Nature 587, 98–102 (2020).

    Article  CAS  Google Scholar 

  7. Min, S. Y. et al. Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells. Proc. Natl Acad. Sci. USA 116, 17970–17979 (2019).

    Article  CAS  Google Scholar 

  8. Bäckdahl, J. et al. Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin. Cell Metab. 33, 1869–1882 (2021).

    Article  Google Scholar 

  9. Hepler, C., Vishvanath, L. & Gupta, R. K. Sorting out adipocyte precursors and their role in physiology and disease. Genes Dev. 31, 127–140 (2017).

    Article  CAS  Google Scholar 

  10. Lacasa, D., Taleb, S., Keophiphath, M., Miranville, A. & Clement, K. Macrophage-secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes. Endocrinology 148, 868–877 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

    Camilla Scheele

  2. ETH Zürich, Department of Health Science and Technologies, Schwerzenbach, Switzerland

    Christian Wolfrum

Authors
  1. Camilla Scheele
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christian Wolfrum
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Christian Wolfrum.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Scheele, C., Wolfrum, C. Functional diversity of human adipose tissue revealed by spatial mapping. Nat Rev Endocrinol 17, 713–714 (2021). https://doi.org/10.1038/s41574-021-00582-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41574-021-00582-2

  • Springer Nature Limited

This article is cited by

Search

Navigation