An emerging feature of type 1 diabetes mellitus and type 2 diabetes mellitus is their association with pulmonary fibrosis, which negatively affects the prognosis of patients. Here, we provide a brief update of the field and the remaining open questions.
References
Kopf, S. et al. Breathlessness and restrictive lung disease: an important diabetes-related feature in patients with type 2 diabetes. Respiration 96, 29–40 (2018).
Kumar, V. et al. Compromised DNA repair is responsible for diabetes-associated fibrosis. EMBO J. 39, e103477 (2020).
Khateeb, J., Fuchs, E. & Khamaisi, M. Diabetes and lung disease: a neglected relationship. Rev. Diabet. Stud. 15, 1–15 (2019).
American Thoracic Society & European Respiratory Society. American Thoracic Society/European Respiratory Society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias. Am. J. Respir. Crit. Care Med. 165, 277–304 (2002).
Davis, W. A. et al. Glycemic exposure is associated with reduced pulmonary function in type 2 diabetes: the Fremantle Diabetes Study. Diabetes Care 27, 752–757 (2004).
Schnack, C., Festa, A., Schwarzmaier-D’Assie, A., Haber, P. & Schernthaner, G. Pulmonary dysfunction in type 1 diabetes in relation to metabolic long-term control and to incipient diabetic nephropathy. Nephron 74, 395–400 (1996).
Kreuter, M. et al. Impact of comorbidities on mortality in patients with idiopathic pulmonary fibrosis. PloS ONE 11, e0151425 (2016).
Kumar, V. et al. Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair. Nucleic Acids Res. 45, 10595–10613 (2017).
Mexas, A. M., Hess, R. S., Hawkins, E. C. & Martin, L. D. Pulmonary lesions in cats with diabetes mellitus. J. Vet. Intern. Med. 20, 47–51 (2006).
Schafer, M. J. et al. Cellular senescence mediates fibrotic pulmonary disease. Nat. Commun. 8, 14532 (2017).
Acknowledgements
The authors acknowledge the support of Deutsche Forschungsgemeinschaft (SFB 1118 & GRK 1874-DIAMICOM) and the Deutsche Zentrum für Diabetesforschung (DZD). The authors acknowledge all the work that could not be cited due to space limitations.
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Kumar, V., Nawroth, P.P. Is the association between diabetes mellitus and pulmonary fibrosis real?. Nat Rev Endocrinol 17, 703–704 (2021). https://doi.org/10.1038/s41574-021-00577-z
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DOI: https://doi.org/10.1038/s41574-021-00577-z
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