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ADIPOSE TISSUE

TIM4+ adipose tissue-resident macrophages: new modulators of adiposity

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Adipose tissue macrophages (ATMs) have important roles in the regulation of inflammatory responses and insulin resistance in obesity. A new study reports that a subpopulation of ATMs, TIM4+ resident ATMs, modulate adipocyte size via platelet-derived growth factor-CC production during development and diet-induced adipose tissue expansion.

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Fig. 1: Distinct roles of adipose tissue macrophages.

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Acknowledgements

The authors acknowledge the support of a National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT; NRF-2020R1A3B2078617 to J.B.K., NRF-2021R1C1C2010446 to J.Y.H.).

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Authors and Affiliations

  1. Center for Adipocyte Structure and Function, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University, Seoul, South Korea

    Jin Young Huh & Jae Bum Kim

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  1. Jin Young Huh
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  2. Jae Bum Kim
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Correspondence to Jae Bum Kim.

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The authors declare no competing interests.

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Huh, J.Y., Kim, J.B. TIM4+ adipose tissue-resident macrophages: new modulators of adiposity. Nat Rev Endocrinol 17, 645–646 (2021). https://doi.org/10.1038/s41574-021-00554-6

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