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A new way to ignite thermogenesis in human adipose tissue

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Thermogenic adipose tissue is a metabolic sink for excess fuel and is a promising target for the treatment of obesity and type 2 diabetes mellitus. However, hurdles exist in activating thermogenic adipose tissue in humans. A new study developed a drug screening platform utilizing human beige adipose tissue and identified non-canonical activators.

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Fig. 1: Adipose-derived stem cell pipeline for metabolic treatment.

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Authors and Affiliations

  1. Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA

    Anthony R. P. Verkerke & Shingo Kajimura

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  1. Anthony R. P. Verkerke
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  2. Shingo Kajimura
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Correspondence to Shingo Kajimura.

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The authors declare no competing interests.

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Verkerke, A.R.P., Kajimura, S. A new way to ignite thermogenesis in human adipose tissue. Nat Rev Endocrinol 16, 475–476 (2020). https://doi.org/10.1038/s41574-020-0390-4

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