Jessica D. Forbes and colleagues found that infants who received formula early in life were more likely to be overweight at 1 year of age than those exclusively breastfed. Formula feeding was associated with altered intestinal microbiome characteristics at 3 months. These findings link early-life formula feeding and an altered microbiome with subsequent overweight.
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References
Forbes, J. D. et al. Association of exposure to formula in the hospital and subsequent infant feeding practices with gut microbiota and risk of overweight in the first year of life. JAMA Pediatr. https://doi.org/10.1001/jamapediatrics.2018.1161 (2018).
Pannaraj, P. S. et al. Association between breast milk bacterial communities and establishment and development of the infant gut microbiome. JAMA Pediatr. 171, 647–654 (2017).
Blaser, M. J. Who are we? Indigenous microbes and the ecology of human diseases. EMBO Reports 7, 956–960 (2006).
Moeller, A. H. et al. Cospeciation of gut microbiota with hominids. Science 353, 380–382 (2016).
Marcobal, A. et al. Consumption of human milk oligosaccharides by gut-related microbes. J. Agric. Food Chem. 58, 5334–5340 (2010).
Cox, L. M. et al. Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell 158, 705–721 (2014).
Hirsch, J. & Han, P. W. Cellularity of rat adipose tissue: effects of growth, starvation, and obesity. J. Lipid Res. 10, 77–82 (1969).
Gibbs, B. G. & Forste, R. Socioeconomic status, infant feeding practices and early childhood obesity. Pediatr. Obes. 9, 135–146 (2014).
Li, R., Fein, S. B. & Grummer-Strawn, L. M. Do infants fed from bottles lack self-regulation of milk intake compared with directly breastfed infants? Pediatrics 125, e1386–e1393 (2010).
Acknowledgements
The authors are supported by U01AI222285, from the National Institutes of Health and the C & D Fund to M.B. The authors thank I. Goldberg for his critical insights.
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Mueller, E., Blaser, M. Breast milk, formula, the microbiome and overweight. Nat Rev Endocrinol 14, 510–511 (2018). https://doi.org/10.1038/s41574-018-0066-5
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DOI: https://doi.org/10.1038/s41574-018-0066-5
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