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Immunotherapy for glioblastoma: quo vadis?

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Glioblastoma remains essentially incurable, and new therapeutic approaches are urgently needed. Now, the findings of three serial tissue-based studies suggest that immune-checkpoint inhibition can modify the glioblastoma microenvironment. Following these encouraging observations, the results of two phase III trials of immune-checkpoint inhibition in newly diagnosed glioblastoma, with larger cohorts of patients, are eagerly anticipated.

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Authors and Affiliations

  1. Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland

    Michael Weller

  2. CHU Lille, Neuro-oncology, General and Stereotaxic Neurosurgery Service, Lille, France

    Emilie Le Rhun

Authors
  1. Michael Weller
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  2. Emilie Le Rhun
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Correspondence to Michael Weller.

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Competing interests

M.W. has received research grants from Abbvie, Adastra, Dracen, Merck, Sharp & Dohme (MSD), Merck (EMD), Novocure, OGD2, Piqur and Roche and honoraria for lectures, participation in advisory boards and/or consultancy from Abbvie, Basilea, Bristol-Myers Squibb, Celgene, MSD, Merck (EMD), Novocure, Orbus, Roche and Tocagen. E.L.R. has received research grants Amgen, Mundipharma; honoraria for lectures or participation in advisory boards for Abbvie, Daiichi-Sankyo and Novartis.

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Weller, M., Le Rhun, E. Immunotherapy for glioblastoma: quo vadis?. Nat Rev Clin Oncol 16, 405–406 (2019). https://doi.org/10.1038/s41571-019-0195-3

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