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Oligosaccharide synthesis

Tailor-made glycans

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A highly chemoselective method for the insertion of carbohydrates into existing oligosaccharides has been developed. The reaction sequence involves a selective Lewis-acid catalysed cleavage of one glycosidic bond followed by sequential construction of two new glycosidic bonds.

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Fig. 1: Cut–Insert–Stich Editing Reaction (CIStER) in theory and in practice.

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Authors and Affiliations

  1. Department of Chemistry, Northeastern University, Boston, MA, USA

    Sugyeom Kim & George A. O’Doherty

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  1. Sugyeom Kim
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  2. George A. O’Doherty
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Correspondence to George A. O’Doherty.

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The authors declare no competing interests.

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Kim, S., O’Doherty, G.A. Tailor-made glycans. Nat Rev Chem 8, 298–299 (2024). https://doi.org/10.1038/s41570-024-00598-y

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