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Protein–peptide interactions

Rapid capture of small peptide binders

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Late-stage modification of peptides with photoactivatable groups often weakens their binding interaction with target proteins. Now, this challenge has been addressed using large libraries of cyclic peptides with photocrosslinkers incorporated prior to screening.

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Fig. 1: Operation of the photocrosslinking-RaPID system.

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Authors and Affiliations

  1. Department of Chemistry, Trinity College Dublin, Dublin, Ireland

    Susannah H. Calvert & Joanna F. McGouran

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  1. Susannah H. Calvert
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  2. Joanna F. McGouran
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Correspondence to Joanna F. McGouran.

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The authors declare no competing interests.

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Calvert, S.H., McGouran, J.F. Rapid capture of small peptide binders. Nat Rev Chem 7, 534–535 (2023). https://doi.org/10.1038/s41570-023-00517-7

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