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CARDIAC DEVELOPMENT

Mouse gastruloids take heart

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Mouse embryonic organoids that model cardiac development ex vivo could be used as a high-throughput, experimentally tractable system to evaluate crucial cell populations and environmental factors that contribute to normal and abnormal cardiogenesis.

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Fig. 1: Gastruloids derived from mouse embryonic stem cells capture early heart development until formation of a primitive heart tube.

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Acknowledgements

The authors thank K. Claiborn (Gladstone Institutes, San Francisco, CA, USA) for editorial assistance and A. Silva (Gladstone Institutes, San Francisco, CA, USA) for assistance with preparing the figure before submission.

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Authors and Affiliations

  1. Gladstone Institutes, San Francisco, CA, USA

    Deepak Srivastava & Todd C. McDevitt

  2. Departments of Pediatrics and Biochemistry & Biophysics, University of California San Francisco, San Francisco, CA, USA

    Deepak Srivastava

  3. Roddenberry Stem Cell Center, Gladstone Institutes, San Francisco, CA, USA

    Deepak Srivastava & Todd C. McDevitt

  4. Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA

    Todd C. McDevitt

Authors
  1. Deepak Srivastava
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  2. Todd C. McDevitt
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Correspondence to Deepak Srivastava or Todd C. McDevitt.

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The authors declare no competing interests.

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Srivastava, D., McDevitt, T.C. Mouse gastruloids take heart. Nat Rev Cardiol 18, 233–234 (2021). https://doi.org/10.1038/s41569-020-00501-4

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