Orderly or coherent multicellular flows are fundamental in biology, but their triggers are not understood. In epithelial tissues, the tug-of-war between cells is now shown to lead to intrinsic asymmetric distributions in cell polarities that drive such flows.
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References
Stramer, B. & Mayor, R. Nat. Rev. Mol. Cell Biol. 18, 43–55 (2017).
Lo Vecchio, S., Pertz, O., Szopos, M., Navoret, L. & Riveline, D. Nat. Phys. https://doi.org/10.1038/s41567-023-02295-x (2024).
Trepat, X. et al. Nat. Phys. 5, 426–430 (2009).
Turing, A. M. Phil. Trans. R. Soc. Lond. B 237, 37–72 (1952).
Arnold, T. R., Stephenson, R. E. & Miller, A. L. Exp. Cell Res. 358, 20–30 (2017).
Lomakin, A. J. et al. Nat. Cell Biol. 17, 1435–1445 (2015).
Lecuit, T. & Yap, A. S. Nat. Cell Biol. 17, 533–539 (2015).
Murrell, M., Oakes, P. W., Lenz, M. & Gardel, M. L. Nat. Rev. Mol. Cell. Biol. 16, 486–498 (2015).
Wu, Y. I. et al. Nature 461, 104–108 (2009).
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Gomez, G.A. Cells play tug-of-war to start moving collectively. Nat. Phys. 20, 189–190 (2024). https://doi.org/10.1038/s41567-023-02314-x
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DOI: https://doi.org/10.1038/s41567-023-02314-x
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