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Soft high-density neural probes enable stable single-neuron recordings

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Using fluorinated elastomers in the fabrication of soft neural probes is shown to enhance spatiotemporal recording capability at single-neuron resolution within the central nervous system of rodents. Other soft encapsulation materials could be similarly engineered for high-resolution, long-lasting bioelectronics.

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Fig. 1: Soft, scalable neural probes.

References

  1. Steinmetz, N. A. et al. Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings. Science 372, eabf4588 (2021). This paper reports high-density neural recording using rigid probes and algorithms to compensate for signal drift.

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This is a summary of: Le Floch, F. et al. 3D spatiotemporally scalable in vivo neural probes based on fluorinated elastomers. Nat. Nanotechnol. https://doi.org/10.1038/s41565-023-01545-6 (2023).

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Soft high-density neural probes enable stable single-neuron recordings. Nat. Nanotechnol. 19, 277–278 (2024). https://doi.org/10.1038/s41565-023-01546-5

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