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Carbon nanotubes activate inflammatory signalling through binding to Siglec-14

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Discovery of a novel axis through which multi-walled carbon nanotubes (MWCNTs) elicit toxicity in human macrophages, involving the propagation of inflammatory signalling via the Siglec-14-DAP12-Syk pathway, and how it may be controlled pharmacologically.

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Fig. 1: MWCNT toxicity mediated via Siglec-14 and potential mitigation approaches.

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Authors and Affiliations

  1. Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast, UK

    Michelle K. Greene & Christopher J. Scott

  2. Aviceda Glycotech, Belfast, UK

    Michelle K. Greene & Christopher J. Scott

Authors
  1. Michelle K. Greene
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  2. Christopher J. Scott
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Corresponding author

Correspondence to Christopher J. Scott.

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Competing interests

M.K.G. and C.J.S. own shares in Aviceda Therapeutics and Avilect Biosciences.

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Greene, M.K., Scott, C.J. Carbon nanotubes activate inflammatory signalling through binding to Siglec-14. Nat. Nanotechnol. 18, 544–545 (2023). https://doi.org/10.1038/s41565-023-01420-4

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