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CANCER IMMUNOLOGY

Cancer cells hijack T-cell mitochondria

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Nanotube-mediated acquisition of immune cells’ mitochondria by tumour cells is a novel mechanism for immune evasion that can be pharmacologically targeted to potentiate cancer immunotherapies.

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Fig. 1: Pharmacological blockade of mitochondrial hijacking improves T-cell antitumour immunity.

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Authors and Affiliations

  1. Regensburg Center for Interventional Immunology, Department of Functional Immune Cell Modulation, Regensburg, Germany

    Jeremy G. Baldwin & Luca Gattinoni

  2. University of Regensburg, Regensburg, Germany

    Luca Gattinoni

Authors
  1. Jeremy G. Baldwin
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  2. Luca Gattinoni
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Corresponding author

Correspondence to Luca Gattinoni.

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Competing interests

L.G. has consulting agreements with Lyell Immunopharma, AstraZeneca, Turnstone Biologics, Xcelcyte. L.G. is on the scientific advisory board of Poseida Therapeutics and Kiromic, and a stockholder of Poseida Therapeutics. J.G.B. declares no competing interests.

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Baldwin, J.G., Gattinoni, L. Cancer cells hijack T-cell mitochondria. Nat. Nanotechnol. 17, 3–4 (2022). https://doi.org/10.1038/s41565-021-01006-y

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