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CANCER NANOMEDICINE

Winning the war with iron

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An FDA-approved iron oxide nanoparticle used for the treatment of anaemia can be repurposed for leukaemia therapy.

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Fig. 1: Proposed mechanism by which ferumoxytol induces selective cell death in leukaemic cells that express low levels of FPN.

References

  1. Crichton, R. in Iron Metabolism: From Molecular Mechanisms to Clinical Consequences (ed. Crichton, R.) 22–70 (Wiley, 2016).

  2. Torti, S. V., Manz, D. H., Paul, B. T., Blanchette-Farra, N. & Torti, F. M. Annu. Rev. Nutr. 38, 97–125 (2018).

    Article  CAS  Google Scholar 

  3. Daniels, T. R. et al. Biochim. Biophys. Acta 1820, 291–317 (2012).

    Article  CAS  Google Scholar 

  4. Pinnix, Z. K. et al. Sci. Transl. Med. 2, 43ra56 (2010).

    Article  Google Scholar 

  5. Gu, Z. et al. Cancer Res. 75, 2211–2221 (2015).

    Article  CAS  Google Scholar 

  6. Trujillo-Alonso, V. et al. Nat. Nanotechnol. https://doi.org/10.1038/s41565-019-0406-1 (2019).

  7. Balakrishnan, V. S. et al. Eur. J. Clin. Invest. 39, 489–496 (2009).

    Article  CAS  Google Scholar 

  8. Vadhan-Raj, S. et al. Am. J. Hematol. 89, 7–12 (2014).

    Article  CAS  Google Scholar 

  9. Zanganeh, S. et al. Nat. Nanotechnol. 11, 986–994 (2016).

    Article  CAS  Google Scholar 

  10. Schoenfeld, J. D. et al. Cancer Cell 32, 268 (2017).

    Article  CAS  Google Scholar 

  11. Kalinowski, D. S. et al. Biochim. Biophys. Acta 1863, 727–748 (2016).

    Article  CAS  Google Scholar 

  12. Toth, G. B. et al. Kidney Int. 92, 47–66 (2017).

    Article  CAS  Google Scholar 

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Correspondence to Suzy V. Torti or Frank M. Torti.

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Torti, S.V., Torti, F.M. Winning the war with iron. Nat. Nanotechnol. 14, 499–500 (2019). https://doi.org/10.1038/s41565-019-0419-9

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