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CANCER NANOMEDICINE

A synthetic lethal bullet

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Nanoparticles loaded with paclitaxel and nintedanib induce synthetic lethality in endometrial cancer cells.

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Fig. 1: TPGS–PLGA nanoparticles loaded with nintedanib and paclitaxel extravasate through the leaky tumour vasculature and reach tumour cells.

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Authors and Affiliations

  1. Early Clinical Trials Unit, Oncology Department, Antwerp University Hospital, Edegem, Belgium

    Christian Rolfo

  2. Center for Oncological Research, University of Antwerp, Edegem, Belgium

    Christian Rolfo

  3. Department of Medical Oncology, Cancer Center Amsterdam, VU University medical center, Amsterdam, The Netherlands

    Elisa Giovannetti

  4. Cancer Pharmacology Lab, AIRC-Start-Up Unit, Pisa, Italy

    Elisa Giovannetti

Authors
  1. Christian Rolfo
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  2. Elisa Giovannetti
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Correspondence to Christian Rolfo or Elisa Giovannetti.

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Rolfo, C., Giovannetti, E. A synthetic lethal bullet. Nature Nanotech 13, 6–7 (2018). https://doi.org/10.1038/s41565-017-0038-2

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