Human norovirus infection is a major global health concern, but a suitable animal model is lacking. We have established repeated infection with human norovirus in rhesus macaques via oral challenge. Animals demonstrate virus shedding in the stool and subsequent serum antibody responses, and virus replication is detected in the small intestine.
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This is a summary of: Rimkute, I. et al. A non-human primate model for human norovirus infection. Nat. Microbiol. https://doi.org/10.1038/s41564-023-01585-7 (2024).
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A rhesus macaque model of human norovirus infection. Nat Microbiol 9, 593–594 (2024). https://doi.org/10.1038/s41564-023-01597-3
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DOI: https://doi.org/10.1038/s41564-023-01597-3
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