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Fungal pathogenesis

Metabolic sensing tips the balance of drug tolerance in fungal meningitis

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Sensing of brain glucose by the fungal pathogen Cryptococcus neoformans alters lipid metabolism and membrane composition in the fungus, rendering it drug tolerant.

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Fig. 1: Glucose sensing alters Cryptococcus membrane composition leading to AmB tolerance.

References

  1. Brown, G. D. et al. Sci. Transl. Med. 4, 165rv13 (2012).

    Article  PubMed  Google Scholar 

  2. Chen, L. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-023-01561-1 (2024).

    Article  PubMed  Google Scholar 

  3. Perfect, J. R. et al. Clin. Infect. Dis. 50, 291–322 (2010).

    Article  PubMed  Google Scholar 

  4. Maji, A. et al. Nature 623, 1079–1085 (2023).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Berman, J. & Krysan, D. J. Nat. Rev. Microbiol. 18, 319–331 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Delarze, E. & Sanglard, D. Drug Resist. Updat. 23, 12–19 (2015).

    Article  PubMed  Google Scholar 

  7. Rosenberg, A. et al. Nat. Commun. 9, 2470 (2018).

    Article  ADS  PubMed  PubMed Central  Google Scholar 

  8. Levinson, T. et al. Mycoses 64, 78–85 (2021).

    Article  CAS  PubMed  Google Scholar 

  9. Rueda, C. et al. Clin. Microbiol. Infect. 23, 49.e1–49.e8 (2017).

    Article  CAS  PubMed  Google Scholar 

  10. Lee, M. K. et al. Mycoses 50, 148–149 (2007).

    Article  CAS  PubMed  Google Scholar 

  11. Yang, F. et al. mBio 14, e0022723 (2023).

  12. Robbins, N., Wright, G. D. & Cowen, L. E. Microbiol. Spectr. https://doi.org/10.1128/microbiolspec.funk-0002-2016 (2016).

  13. Shaw, K. J. & Ibrahim, A. S. J. Fungi https://doi.org/10.3390/jof6040239 (2020).

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Authors and Affiliations

  1. Shmunis School of Biomedical and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel

    Austin Mottola & Judith Berman

  2. Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin, Berlin, Germany

    Johannes Hartl & Markus Ralser

  3. Charité – Universitätsmedizin Berlin, Department of Biochemistry, Berlin, Germany

    Markus Ralser

  4. The Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK

    Markus Ralser

  5. Max Planck Institute for Molecular Genetics, Berlin, Germany

    Markus Ralser

  6. Edmond J. Safra Center for Bioinformatics, Tel Aviv University, Ramat Aviv, Israel

    Judith Berman

Authors
  1. Austin Mottola
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  2. Johannes Hartl
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  3. Markus Ralser
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  4. Judith Berman
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Corresponding author

Correspondence to Judith Berman.

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Competing interests

M.R. is a founder and a shareholder of Elitpca Ltd. All other authors declare no competing interests.

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Mottola, A., Hartl, J., Ralser, M. et al. Metabolic sensing tips the balance of drug tolerance in fungal meningitis. Nat Microbiol 9, 316–317 (2024). https://doi.org/10.1038/s41564-023-01595-5

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