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Staphylococcus aureus PSMs are a double-edged sword

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Immunologic recognition of bacterial products during skin infection triggers a cytokine and chemokine response that facilitates neutrophil recruitment to the site of infection. Staphylococcus aureus phenol-soluble modulins can function as early chemoattractants to directly recruit neutrophils and alert the host to infection.

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Fig. 1: The S. aureus–host balance.

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Authors and Affiliations

  1. Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA

    Leslie A. Fogel & Juliane Bubeck Wardenburg

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  1. Leslie A. Fogel
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  2. Juliane Bubeck Wardenburg
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Correspondence to Juliane Bubeck Wardenburg.

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Competing interests

J.B.W. has a financial agreement with Aridis Pharmaceuticals related to patents owned by the University of Chicago.

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Fogel, L.A., Bubeck Wardenburg, J. Staphylococcus aureus PSMs are a double-edged sword. Nat Microbiol 7, 12–13 (2022). https://doi.org/10.1038/s41564-021-01040-5

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