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VIRAL INFECTION

CRISPR inactivation by integration

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A Publisher Correction to this article was published on 08 December 2021

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Bacteriophages fight back with the double whammy of an anti-CRISPR protein and integration into the CRISPR array to protect themselves from the CRISPR–Cas9 immune system of Streptococcus pyogenes.

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Fig. 1: Phage defence against CRISPR–Cas9 immunity via the combination of an anti-CRISPR protein and integration into the CRISPR array.

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References

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA

    Joseph Bondy-Denomy

  2. Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA, USA

    Joseph Bondy-Denomy

  3. Innovative Genomics Institute, Berkeley, CA, USA

    Joseph Bondy-Denomy

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  1. Joseph Bondy-Denomy
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Correspondence to Joseph Bondy-Denomy.

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Competing interests

J.B.-D. is a member of the scientific advisory board of SNIPR Biome and Excision Biotherapeutics and co-founder and chair of the scientific advisory board of Acrigen Biosciences. The Bondy-Denomy lab has a sponsored research agreement with Felix Biotechnology.

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Bondy-Denomy, J. CRISPR inactivation by integration. Nat Microbiol 6, 1475–1476 (2021). https://doi.org/10.1038/s41564-021-01007-6

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