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Viral RNA in an m6A disguise

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N6-methyladenosine (m6A) is a widespread modification on cellular RNA that is dynamically regulated involving m6A writers, erasers and readers, and can impact many cellular processes and pathways. A recent study demonstrates that viruses can use m6A to ensure their RNA avoids innate immune sensing.

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Fig. 1: Interplay between viral RNA synthesis, the cellular m6A modification system and RNA innate immune sensing.

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Acknowledgements

V.T. was supported by the Swiss National Science Foundation (SNF, grant no. 310030_173085).

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Authors and Affiliations

  1. Institute of Virology and Immunology, Bern, Switzerland

    Volker Thiel

  2. Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland

    Volker Thiel

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  1. Volker Thiel
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Correspondence to Volker Thiel.

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Thiel, V. Viral RNA in an m6A disguise. Nat Microbiol 5, 531–532 (2020). https://doi.org/10.1038/s41564-020-0689-x

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