Metabolic adaptation plays a key role in determining the composition of microbial ecosystems. A new study shows that in the inflamed gut, pathogenic Enterobacteriaceae can reprogramme their metabolism towards diet-derived l-serine utilization to outcompete the resident microbiota and cause disease.
References
Brestoff, J. R. & Artis, D. Nat. Immunol. 14, 767–684 (2014).
Winter, S. E. & Baumler, A. J. Gut Microbes 5, 71–73 (2014).
Shin, N. R., Whon, T. W. & Bae, J. W. Trends Biotechnol. 33, 496–503 (2015).
Darfeuille-Michaud, A. et al. Gastroenterology 115, 1405–1413 (1998).
Kitamoto, S. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-019-0591-6 (2019).
Chang, D. E. et al. Proc. Natl Acad. Sci. USA 101, 7427–7432 (2004).
Faber, F. & Baumler, A. J. Immunol. Lett. 162, 48–53 (2014).
Nuccio, S.-P. & Baumler, A. J. mBio 5, e00929-14 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Yoo, W., Byndloss, M.X. How to thrive in the inflamed gut. Nat Microbiol 5, 10–11 (2020). https://doi.org/10.1038/s41564-019-0642-z
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41564-019-0642-z
- Springer Nature Limited
This article is cited by
-
Gut-host Crosstalk: Methodological and Computational Challenges
Digestive Diseases and Sciences (2020)