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Chronic infection by controlling inflammation

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Molecular players involved in systemic and acute infections are relatively easy to pinpoint, whereas bacterial resilience during chronic infections remains less well understood. Pseudomonas aeruginosa encodes a quorum-regulated virulence factor, TesG, that promotes chronic lung infection by suppressing host inflammatory responses.

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Fig. 1: Model for TesG suppression of inflammation.

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Authors and Affiliations

  1. Department of Life Sciences, MRC Centre for Molecular Microbiology and Infection, Imperial College, London, UK

    Alain Filloux

  2. The Cystic Fibrosis and Chronic Infection Group, National Heart and Lung Institute, Imperial College, London, UK

    Jane C. Davies

  3. The Royal Brompton and Harefield NHS Foundation Trust, London, UK

    Jane C. Davies

Authors
  1. Alain Filloux
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  2. Jane C. Davies
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Correspondence to Alain Filloux or Jane C. Davies.

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The authors declare no competing interests.

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Filloux, A., Davies, J.C. Chronic infection by controlling inflammation. Nat Microbiol 4, 378–379 (2019). https://doi.org/10.1038/s41564-019-0397-6

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