The bacterial pathogen Staphylococcus aureus secretes a high-affinity insulin-binding protein that mediates insulin resistance, a major driver of obesity and type 2 diabetes, in a mouse model of infection.
References
Haeusler, R. A., McGraw, T. E. & Accili, D. Nat. Rev. Mol. Cell Biol. 19, 31–44 (2017).
Olsen, K. et al. PLoS ONE 8, e63716 (2013).
Smit, J. et al. Eur. J. Endocrinol. 174, 631–639 (2016).
Vu, B. G. et al. mBio 6, e02554 (2015).
Kahn, S. E., Hull, R. L. & Utzschneider, K. M. Nature 444, 840–846 (2006).
Liu, Y. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0146-2 (2018).
Donath, M. Y. & Shoelson, S. E. Nat. Rev. Immunol. 11, 98–107 (2011).
Spaulding, A. R. et al. Clin. Microbiol. Rev. 26, 422–47 (2013).
Hanses, F., Roux, C., Dunman, P. M., Salzberger, B. & Lee, J. C. Genome Med. 6, 93 (2014).
Schlievert, P. M., Salgado-Pabón, W. & Klingelhutz, A. J. Future Microbiol. 10, 1549–1552 (2015).
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Weidenmaier, C. Staphylococcus aureus blocks insulin function. Nat Microbiol 3, 533–534 (2018). https://doi.org/10.1038/s41564-018-0153-3
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DOI: https://doi.org/10.1038/s41564-018-0153-3
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